Article

The histone H3.3 K27M mutation found in diffuse midline gliomas coordinately disrupts adjacent H3.3 Ser31 phosphorylation and the fidelity of chromosome segregation

2022-05-28

Abstract excerpt

During the cell cycle, differential phosphorylation of select histone H3 serine/threonine residues regulates chromatin structure, necessary for both dynamic transcriptional control and proper chromosome segregation 1-2 . Histone H3.3 contains a highly conserved serine residue (Ser31) within its N-terminal tail that is unique to this variant. During interphase phosphorylation of Ser31 amplifies stimulation-induced...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6897cf00-da1a-5e8d-b550-a7ff39ae94c9
DOI: 10.1101/2022.05.27.493485

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The histone H3.3 K27M mutation found in diffuse midline gliomas coordinately disrupts adjacent H3.3 Ser31 phosphorylation and the fidelity of chromosome segregationDOI 10.1101/2022.05.27.493485Read

The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis.Semantic proximity Read

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.Semantic proximity Read

Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.Semantic proximity Read

H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma.Semantic proximity Read

Cooperativity between H3.3K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatarsSemantic proximity Read

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric gliomaSemantic proximity Read

Local inhibition of PRC2 activity by H3.3K27M drives DNA replication defects through misregulation of the JNK pathwaySemantic proximity Read

Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.Semantic proximity Read

Evidence for coordinate CTCF and histone H3.3 activities in K27M diffuse midline gliomas.Semantic proximity Read

H3F3A K27M Mutations Drives a Repressive Transcriptome by Modulating Chromatin Accessibility, Independent of H3K27me3 in Diffuse Midline GliomaSemantic proximity Read

STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma.Semantic proximity Read

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.Semantic proximity Read