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Article

Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.

Nature genetics - 1 Aug 2021

Brien Gerard L, Bressan Raul Bardini, Monger Craig, Gannon Dáire, Lagan Eimear, Doherty Anthony M, Healy Evan, Neikes Hannah, Fitzpatrick Darren J, Deevy Orla, Grant Vivien, Marqués-Torrejón Maria-Angeles, Alfazema Neza, Pollard Steven M, Bracken Adrian P

Abstract excerpt

Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we use human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context. Genome-wide mapping of...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34294917
DOI: 10.1038/s41588-021-00897-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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