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Article

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.

Science (New York, N.Y.) - 29 Aug 2014

Herz Hans-Martin, Morgan Marc, Gao Xin, Jackson Jessica, Rickels Ryan, Swanson Selene K, Florens Laurence, Washburn Michael P, Eissenberg Joel C, Shilatifard Ali

Abstract excerpt

Histone H3 lysine(27)-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes and developmental perturbations. Similarly, an H3K9M mutant...

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Identifiers

PMID: 25170156
DOI: 10.1126/science.1255104
PMCID: PMC4508193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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