Article
An E2 ubiquitin-conjugating enzyme links diubiquitinated H2B to H3K27M oncohistone function.
Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2024
Jiao Alan L, Sendinc Erdem, Zee Barry M, Wallner Felice, Shi Yang
Abstract excerpt
The H3K27M oncogenic histone (oncohistone) mutation drives ~80% of incurable childhood brain tumors known as diffuse midline gliomas (DMGs). The major molecular feature of H3K27M mutant DMGs is a global loss of H3K27 trimethylation (H3K27me3), a phenotype conserved in Caenorhabditis elegans (C. elegans). Here, we perform unbiased genome-wide suppressor screens in C. elegans expressing H3K27M and isolate 20...
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