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Article

Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones.

eLife - 9 Sept 2020

Sarthy Jay F, Meers Michael P, Janssens Derek H, Henikoff Jorja G, Feldman Heather, Paddison Patrick J, Lockwood Christina M, Vitanza Nicholas A, Olson James M, Ahmad Kami, Henikoff Steven

Abstract excerpt

Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown how oncohistone type affects gliomagenesis. We show that the genomic distributions of H3.1 and H3.3 oncohistones in human patient-derived DMG cells are consistent with...

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Identifiers

PMID: 32902381
DOI: 10.7554/eLife.61090
PMCID: PMC7518889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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