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Article

Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer

4 Dec 2020

Abstract excerpt

Histone H3 lysine 27 (H3K27M) mutations represent the canonical oncohistone, occurring frequently in midline gliomas but also identified in haematopoietic malignancies and carcinomas. H3K27M functions, at least in part, through widespread changes in H3K27 trimethylation but its role in tumour initiation remains obscure. To address this, we created a transgenic mouse expressing H3.3K27M in diverse progenitor cell...

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PMID: 33277484
DOI: 10.1038/s41467-020-19972-7

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