Article

Neurons expressing pathological Tau protein trigger dramatic changes in microglial morphology and dynamics

2019-08-12

Abstract excerpt

Microglial cells, the resident macrophages of the brain, are important players in the pathological process of numerous neurodegenerative disorders, including tauopathies, a heterogeneous class of diseases characterized by intraneuronal Tau aggregates. However, microglia response in Tau pathologies remains poorly understood. Here we exploit a genetic zebrafish model of tauopathy, combined with live microglia imagin...

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Literature Corpus work: e09b722f-da43-599f-906a-25f886aef8d7
DOI: 10.1101/731901

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