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Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice

26 Nov 2024

Abstract excerpt

Unique microglial states have been identified in Alzheimer's disease (AD) model mice and postmortem AD brains. Although it has been well documented that amyloid-β accumulation induces the alteration of microglial states, the relationship between tau pathology and microglial states remains incompletely understood because of a lack of suitable AD models. In the present study, we generated a novel AD model mouse by...

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PMID: 39592224
DOI: 10.1523/eneuro.0260-24.2024

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