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Article

Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer's Disease.

International journal of molecular sciences - 8 Sept 2021

Romero-Molina Carmen, Navarro Victoria, Jimenez Sebastian, Muñoz-Castro Clara, Sanchez-Mico Maria V, Gutierrez Antonia, Vitorica Javier, Vizuete Marisa

Abstract excerpt

Microglia play a critical role in both homeostasis and disease, displaying a wide variety in terms of density, functional markers and transcriptomic profiles along the different brain regions as well as under injury or pathological conditions, such as Alzheimer's disease (AD). The generation of reliable models to study into a dysfunctional microglia context could provide new knowledge towards the contribution of...

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Identifiers

PMID: 34575898
DOI: 10.3390/ijms22189734
PMCID: PMC8471219

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