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Article

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.

PloS one - 1 Jan 2013

Krabbe Grietje, Halle Annett, Matyash Vitali, Rinnenthal Jan L, Eom Gina D, Bernhardt Ulrike, Miller Kelly R, Prokop Stefan, Kettenmann Helmut, Heppner Frank L

Abstract excerpt

Microglial cells closely interact with senile plaques in Alzheimer's disease and acquire the morphological appearance of an activated phenotype. The significance of this microglial phenotype and the impact of microglia for disease progression have remained controversial. To uncover and characterize putative changes in the functionality of microglia during Alzheimer's disease, we directly assessed microglial...

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Share to Amyloid beta-Peptides
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microglia

Share to Phagocytosis

Share to Plaque, Amyloid

Share to Protein Multimerization

Share to Protein Structure, Secondary

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Source

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Identifiers

PMID: 23577177
DOI: 10.1371/journal.pone.0060921
PMCID: PMC3620049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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