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Article

Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.

Brain research - 12 Jun 2008

Sasaki Atsushi, Kawarabayashi Takeshi, Murakami Tetsuro, Matsubara Etsuro, Ikeda Masaki, Hagiwara Haruo, Westaway David, George-Hyslop Peter S, Shoji Mikio, Nakazato Yoichi

Abstract excerpt

The aim of this study is to clarify the relationship of microglia to phosphorylated tau accumulation and the characteristics of microglial activation in brain lesions of human tauopathies in comparison to mutant tau transgenic (TG) mice. We performed immunocytochemical analyses of brains from six patients with tauopathies, and 24 mice (18 TG mice expressing mutant tau P301L and six non-TG control mice, 11 to 27...

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Identifiers

PMID: 18457819
DOI: 10.1016/j.brainres.2008.02.084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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