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Article

Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo

8 Jan 2016

Abstract excerpt

The microtubule-associated protein (MAP) tau plays a critical role in the pathogenesis of tauopathies. Excess tau can be released into the extracellular medium in a physiological or pathological manner to be internalized by surrounding neurons-a process that contributes to the spread of this protein throughout the brain. Such spreading may correlate with the progression of the abovementioned diseases. In addition...

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Identifiers

PMID: 26638867
DOI: 10.3233/jad-150704

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Related research

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