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Article

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.

Neurobiology of aging - 1 May 2020

van Olst Lynn, Verhaege Daan, Franssen Marc, Kamermans Alwin, Roucourt Bart, Carmans Sofie, Ytebrouck Ellen, van der Pol Susanne M A, Wever Dennis, Popovic Marko, Vandenbroucke Roosmarijn E, Sobrino Tomás, Schouten Marijn, de Vries Helga E

Abstract excerpt

Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially culminating into neuronal cell death, a process termed tauopathy. Our aim was to address at which tauopathy stage neuroinflammation starts and to study the related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32008854
DOI: 10.1016/j.neurobiolaging.2020.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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