Article

Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model

2020-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Fibrillary tau pathologies have been implicated in Alzheimer’s and allied neurodegenerative diseases, while mechanisms by which neurons bearing tau tangles die remain enigmatic. To address this issue, we pursued tau and related key pathologies macroscopically by PET and MRI and microscopically by intravital two-photon laser optics. Time-course macroscopic assays of tau transgenic mice demonstrat...

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Literature Corpus work: a451a5b3-1604-5bad-b3df-7f2222b204d3
DOI: 10.1101/2020.11.04.368977

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