Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)

27 Jan 2020

Abstract excerpt

Alzheimer's disease (AD) is the most common type of dementia in the world. The main biomarkers associated with AD are protein amyloid-β (Aβ) plaques and protein tau neurofibrillary tangles, which are responsible for brain neuroinflammation mediated by microglial cells. Increasing evidence has shown that the retina can also be affected in AD, presenting some molecular and cellular changes in the brain, such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neurological Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32012676
DOI: 10.3390/ijms21030816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)PMID 32012676Read ↗

Concomitant AD and DLB pathologies shape subfield microglia responses in the hippocampusSemantic proximity Read ↗

Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD miceSemantic proximity Read ↗

Microglia contributes to plaque growth by cell death due to uptake of amyloid β in the brain of Alzheimer's disease mouse model.Semantic proximity Read ↗

Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.Semantic proximity Read ↗

Neurons expressing pathological Tau protein trigger dramatic changes in microglial morphology and dynamicsSemantic proximity Read ↗

An overview on microglial origin, distribution, and phenotype in Alzheimer's disease.Semantic proximity Read ↗

Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology.Semantic proximity Read ↗

The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and AppNL-F/NL-F miceSemantic proximity Read ↗

Different phenotypes of microglia in animal models of Alzheimer diseaseSemantic proximity Read ↗

Mouse Models of Alzheimer’s DiseaseSemantic proximity Read ↗

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.