Article

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

2021-02-22

Abstract excerpt

Activation of microglia, the brain’s innate immune cells, is a prominent pathological feature in tauopathies, including Alzheimer’s disease. How microglia activation contributes to tau toxicity remains largely unknown. Here we show that nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, activated by tau, drives microglial-mediated tau propagation and toxicity. Constitutive activation...

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Literature Corpus work: bd7e8f40-31cf-5885-b1a5-6ee616904e92
DOI: 10.1101/2021.02.22.432272

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