Article

Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritis

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Autotaxin (ATX) is a lysophospholipase D (lysoPLD) serving as both a lysophosphatidic acid (LPA)-producing enzyme and a LPA docking molecule. ATX binds to the cell surface via interaction with adhesive molecules, including β1-integrin, potentially facilitating LPA access to its specific G protein-coupled receptors. However, the precise protein-protein interaction sequences and their biological i...

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Literature Corpus work: e094b458-76c0-5b78-80d5-88a6226230a8
DOI: 10.1101/2025.04.04.646839

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