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Article

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.

The Journal of biological chemistry - 1 Sept 2006

Tanaka Masayuki, Okudaira Shinichi, Kishi Yasuhiro, Ohkawa Ryunosuke, Iseki Sachiko, Ota Masato, Noji Sumihare, Yatomi Yutaka, Aoki Junken, Arai Hiroyuki

Abstract excerpt

Autotaxin (ATX) is a cancer-associated motogen that has multiple biological activities in vitro through the production of bioactive small lipids, lysophosphatidic acid (LPA). ATX and LPA are abundantly present in circulating blood. However, their roles in circulation remain to be solved. To uncover the physiological role of ATX we analyzed ATX knock-out mice. In ATX-null embryos, early blood vessels appeared to...

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Share to Gene Expression Regulation, Developmental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16829511
DOI: 10.1074/jbc.M605142200

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.PMID 16829511Read ↗

ATX expression and LPA signalling are vital for the development of the nervous system.Semantic proximity Read ↗

Autotaxin–Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic ImplicationsSemantic proximity Read ↗

Autotaxin-Lysophosphatidic Acid Axis Acts Downstream of Apoprotein B Lipoproteins in Endothelial Cells.Semantic proximity Read ↗

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Placental autotaxin expression is diminished in women with pre‐eclampsiaSemantic proximity Read ↗

ATX-LPA receptor axis in inflammation and cancerSemantic proximity Read ↗

Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritisSemantic proximity Read ↗

Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.Semantic proximity Read ↗

Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.Semantic proximity Read ↗

Genetic deletion of Autotaxin from CD11b <sup>+</sup> cells decreases the severity of experimental autoimmune encephalomyelitisSemantic proximity Read ↗

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Autotaxin negatively regulates parathyroid hormone-induced osteogenesis through autocrine inhibition of β-catenin signalingSemantic proximity Read ↗

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