Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATX-LPA receptor axis in inflammation and cancer

15 Nov 2009

Abstract excerpt

Lysophosphatidic acid (LPA, 1- or 2-acyl-sn-glycerol 3-phosphate) mediates a plethora of physiological and pathological activities via interactions with a series of high affinity G protein-coupled receptors (GPCR). Both LPA receptor family members and autotaxin (ATX/LysoPLD), the primary LPA-producing enzyme, are aberrantly expressed in many human breast cancers and several other cancer lineages. Using transgenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol and Lipid Metabolism
Share to Endoplasmic Reticulum Stress and Disease
Share to Sphingolipid Metabolism and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19855166
DOI: 10.4161/cc.8.22.9937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATX-LPA receptor axis in inflammation and cancerPMID 19855166Read ↗

Autotaxin–Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic ImplicationsSemantic proximity Read ↗

Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various CancersSemantic proximity Read ↗

Lysophosphatidic acid receptors in cancer pathobiology.Semantic proximity Read ↗

Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritisSemantic proximity Read ↗

Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.Semantic proximity Read ↗

ATX expression and LPA signalling are vital for the development of the nervous system.Semantic proximity Read ↗

Genetic deletion of Autotaxin from CD11b <sup>+</sup> cells decreases the severity of experimental autoimmune encephalomyelitisSemantic proximity Read ↗

Structural basis of substrate discrimination and integrin binding by autotaxin.Semantic proximity Read ↗

Jatrorrhizine suppresses high-fat diet-associated colorectal cancer by modulating the ATX-LPA-LPAR- MAPK axis to regulate glycerophospholipid metabolismSemantic proximity Read ↗

Autotaxin negatively regulates parathyroid hormone-induced osteogenesis through autocrine inhibition of β-catenin signalingSemantic proximity Read ↗

Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.Semantic proximity Read ↗

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.