Article
Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.
Nature communications - 27 Jan 2021
Norin Ulrika, Rintisch Carola, Meng Liesu, Forster Florian, Ekman Diana, Tuncel Jonatan, Klocke Katrin, Bäcklund Johan, Yang Min, Bonner Michael Y, Lahore Gonzalo Fernandez, James Jaime, Shchetynsky Klementy, Bergquist Maria, Gjertsson Inger, Hubner Norbert, Bäckdahl Liselotte, Holmdahl Rikard
Abstract excerpt
The introduction of the CTLA-4 recombinant fusion protein has demonstrated therapeutic effects by selectively modulating T-cell activation in rheumatoid arthritis. Here we show, using a forward genetic approach, that a mutation in the SH3gl1 gene encoding the endocytic protein Endophilin A2 is associated with the development of arthritis in rodents. Defective expression of SH3gl1 affects T cell effector functions...
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