Structural basis of substrate discrimination and integrin binding by autotaxin.

doi:10.1038/nsmb.1980

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Structural basis of substrate discrimination and integrin binding by autotaxin.

Nature structural & molecular biology - 1 Feb 2011

Hausmann Jens, Kamtekar Satwik, Christodoulou Evangelos, Day Jacqueline E, Wu Tao, Fulkerson Zachary, Albers Harald M H G, van Meeteren Laurens A, Houben Anna J S, van Zeijl Leonie, Jansen Silvia, Andries Maria, Hall Troii, Pegg Lyle E, Benson Timothy E, Kasiem Mobien, Harlos Karl, Kooi Craig W Vander, Smyth Susan S, Ovaa Huib, Bollen Mathieu, Morris Andrew J, Moolenaar Wouter H, Perrakis Anastassis

Abstract excerpt

Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2, ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types. ATX-LPA signaling is involved in various pathologies including tumor progression and inflammation. However, the molecular basis of substrate recognition and catalysis by ATX and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Integrins

Share to Lysophospholipids

Share to Phosphoric Diester Hydrolases

Share to Protein Structure, Tertiary

Share to Pyrophosphatases

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 21240271
DOI: 10.1038/nsmb.1980
PMCID: PMC3064516

Genes

LPA
ENPP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of substrate discrimination and integrin binding by autotaxin.PMID 21240271Read ↗

Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritisSemantic proximity Read ↗

Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.Semantic proximity Read ↗

ATX-LPA receptor axis in inflammation and cancerSemantic proximity Read ↗

Autotaxin–Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic ImplicationsSemantic proximity Read ↗

The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.Semantic proximity Read ↗

An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D.Semantic proximity Read ↗

ATX expression and LPA signalling are vital for the development of the nervous system.Semantic proximity Read ↗

Autotaxin negatively regulates parathyroid hormone-induced osteogenesis through autocrine inhibition of β-catenin signalingSemantic proximity Read ↗

Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.Semantic proximity Read ↗

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.Semantic proximity Read ↗

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7Semantic proximity Read ↗

Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.