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Article

Structural basis of substrate discrimination and integrin binding by autotaxin.

Nature structural & molecular biology - 1 Feb 2011

Hausmann Jens, Kamtekar Satwik, Christodoulou Evangelos, Day Jacqueline E, Wu Tao, Fulkerson Zachary, Albers Harald M H G, van Meeteren Laurens A, Houben Anna J S, van Zeijl Leonie, Jansen Silvia, Andries Maria, Hall Troii, Pegg Lyle E, Benson Timothy E, Kasiem Mobien, Harlos Karl, Kooi Craig W Vander, Smyth Susan S, Ovaa Huib, Bollen Mathieu, Morris Andrew J, Moolenaar Wouter H, Perrakis Anastassis

Abstract excerpt

Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2, ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types. ATX-LPA signaling is involved in various pathologies includi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lysophospholipids

Share to Phosphoric Diester Hydrolases

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Source

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Identifiers

PMID: 21240271
DOI: 10.1038/nsmb.1980
PMCID: PMC3064516

Genes

LPA
ENPP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21240271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Structural basis of substrate discrimination and integrin binding by autotaxin.PMID 21240271Read ↗

Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritisSemantic proximity Read ↗

Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.Semantic proximity Read ↗

ATX-LPA receptor axis in inflammation and cancerSemantic proximity Read ↗

Autotaxin–Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic ImplicationsSemantic proximity Read ↗

The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.Semantic proximity Read ↗

An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D.Semantic proximity Read ↗

ATX expression and LPA signalling are vital for the development of the nervous system.Semantic proximity Read ↗

Autotaxin negatively regulates parathyroid hormone-induced osteogenesis through autocrine inhibition of β-catenin signalingSemantic proximity Read ↗

Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.Semantic proximity Read ↗

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.Semantic proximity Read ↗

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7Semantic proximity Read ↗

Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.Semantic proximity Read ↗

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