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Article

An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D.

The Journal of biological chemistry - 13 Apr 2007

Jansen Silvia, Callewaert Nico, Dewerte Isabelle, Andries Maria, Ceulemans Hugo, Bollen Mathieu

Abstract excerpt

Autotaxin/NPP2, a secreted lysophospholipase-D, promotes cell proliferation, survival, and motility by generating the signaling molecule lysophosphatidic acid. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2) is N-glycosylated on Asn-53, Asn-410, and Asn-524. Mutagenesis and deglycosylation experiments revealed that only the glycosylation of Asn-524 is essential for the expression of...

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PMID: 17307740
DOI: 10.1074/jbc.M611503200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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