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Article

The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.

The Journal of biological chemistry - 2 May 2014

Hewit Kay D, Fraser Alasdair, Nibbs Robert J B, Graham Gerard J

Abstract excerpt

The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory CC-chemokines. Despite its prominent biological role, little is known about the structure/function relationship within...

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Identifiers

PMID: 24644289
DOI: 10.1074/jbc.M113.534545
PMCID: PMC4007430

Genes

ACKR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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