Article

Autotaxin negatively regulates parathyroid hormone-induced osteogenesis through autocrine inhibition of β-catenin signaling

2026-03-13

Abstract excerpt

<title>Abstract</title> <p> Autotaxin (ATX/ENPP2) is a lysophospholipase D responsible for lysophosphatidic acid (LPA) production from lysophosphatidylcholine in biological fluids. LPA controls bone metabolism through interplay between specific LPA receptors. However, because <italic>Enpp2</italic> deletion causes embryonic lethality, ATX functions within the osteoblast cell lineage and its contributions to bo...

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Literature Corpus work: 5f679944-9542-5cdb-85e9-17de209304ee
DOI: 10.21203/rs.3.rs-8853584/v1

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