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Article

ATX expression and LPA signalling are vital for the development of the nervous system.

Developmental biology - 15 Mar 2010

Fotopoulou Stella, Oikonomou Nikos, Grigorieva Elena, Nikitopoulou Ioanna, Paparountas Triantafillos, Thanassopoulou Artemis, Zhao Zhenwen, Xu Yan, Kontoyiannis Dimitris L, Remboutsika Eumorphia, Aidinis Vassilis

Abstract excerpt

Autotaxin (ATX) is a secreted glycoprotein widely present in biological fluids, originally isolated from the supernatant of melanoma cells as an autocrine motility stimulation factor. Its enzymatic product, lysophosphatidic acid (LPA), is a phospholipid mediator that evokes growth-factor-like res...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Lysophospholipids

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Source

Identifiers

PMID: 20079728
DOI: 10.1016/j.ydbio.2010.01.007

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20079728-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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ATX expression and LPA signalling are vital for the development of the nervous system.PMID 20079728Read ↗

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.Semantic proximity Read ↗

Autotaxin–Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic ImplicationsSemantic proximity Read ↗

Genetic deletion of Autotaxin from CD11b <sup>+</sup> cells decreases the severity of experimental autoimmune encephalomyelitisSemantic proximity Read ↗

ATX-LPA receptor axis in inflammation and cancerSemantic proximity Read ↗

ATX expression from GFAP <sup>+</sup> cells is essential for embryonic developmentSemantic proximity Read ↗

Role of ectonucleotide pyrophosphatase/phosphodiesterase 2 in the midline axis formation of zebrafish.Semantic proximity Read ↗

Lysophosphatidic acid controls autotaxin binding to β1-integrin : impact on disease progression in murine collagen-induced arthritisSemantic proximity Read ↗

Autotaxin-Lysophosphatidic Acid Axis Acts Downstream of Apoprotein B Lipoproteins in Endothelial Cells.Semantic proximity Read ↗

Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various CancersSemantic proximity Read ↗

Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.Semantic proximity Read ↗

Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.Semantic proximity Read ↗

Placental autotaxin expression is diminished in women with pre‐eclampsiaSemantic proximity Read ↗

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