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Autotaxin–Lysophosphatidate Axis: Promoter of Cancer Development and Possible Therapeutic Implications

15 Jul 2024

Abstract excerpt

gene. ATX is a secreted glycoprotein and catalyzes the hydrolysis of lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA is responsible for the transduction of various signal pathways through the interaction with at least six G protein-coupled receptors, LPA Receptors 1 to 6 (LPAR1-6). The ATX-LPA axis is involved in various physiological and pathological processes, such as angiogenesis, embryonic...

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PMID: 39062979
DOI: 10.3390/ijms25147737

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