Article

Genetic deletion of Autotaxin from CD11b <sup>+</sup> cells decreases the severity of experimental autoimmune encephalomyelitis

2019-11-20

Abstract excerpt

Autotaxin (ATX) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a growth factor-like signaling lysophospholipid. ATX and LPA signaling have been incriminated in the pathogenesis of different chronic inflammatory diseases and various types of cancer. In this report, deregulated ATX and LPA levels were detected in the spinal cord and plasma of mice during the...

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Literature Corpus work: bbc4f140-300b-59e5-80c7-1903188d09d5
DOI: 10.1101/850149

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