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Article

Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.

Molecular pharmacology - 1 Sept 2013

Fells James I, Lee Sue Chin, Fujiwara Yuko, Norman Derek D, Lim Keng Gat, Tsukahara Ryoko, Liu Jianxiong, Patil Renukadevi, Miller Duane D, Kirby R Jason, Nelson Sandra, Seibel William, Papoian Ruben, Parrill Abby L, Baker Daniel L, Bittman Robert, Tigyi Gabor

Abstract excerpt

Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). A high-throughput screen of ATX inhibition using the lysophosphatidylcholine-like substrate fluorogenic substrate 3 (FS-3)...

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Identifiers

PMID: 23793291
DOI: 10.1124/mol.113.087080
PMCID: PMC3876816

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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