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Nanoparticle Enrichment Mass-Spectrometry Proteomics Identifies Protein Altering Variants for Precise pQTL Mapping

2023-04-21

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) with proteomics generate hypotheses on protein function and offer genetic evidence for drug target prioritization. Although most protein quantitative loci (pQTLs) have so far been identified by high-throughput affinity proteomics platforms, these methods also have some limitations, such as uncertainty about target identity, non-specific binding of aptamers,...

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Literature Corpus work: df4acd78-9ca9-5304-b951-c50b8fa8adac
DOI: 10.1101/2023.04.20.537640

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