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Article

Whole-genome sequencing analysis of the cardiometabolic proteome.

Nature communications - 10 Dec 2020

Gilly Arthur, Park Young-Chan, Png Grace, Barysenka Andrei, Fischer Iris, Bjørnland Thea, Southam Lorraine, Suveges Daniel, Neumeyer Sonja, Rayner N William, Tsafantakis Emmanouil, Karaleftheri Maria, Dedoussis George, Zeggini Eleftheria

Abstract excerpt

The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257 circulating protein biomarkers of cardiometabolic relevance through high-depth (22.5×) whole-genome sequencing (WGS) in 1328 individuals. We discover 131 independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33303764
DOI: 10.1038/s41467-020-20079-2
PMCID: PMC7729872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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