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Article

Epitope Effect Prevalence in Affinity-based pQTL studies

2025-06-24

Abstract excerpt

Affinity-based proteomics platforms Olink and SomaScan have enabled population-wide human proteogenomic studies, linking genetic variants to protein abundances. However, sequence alterations in the binding site of the detection reagent may introduce platform-specific measurement bias unrelated to protein levels, referred to as the epitope effect. In this study, we investigated the prevalence of epitope effects usi...

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Literature Corpus work
344fb3c3-3b5a-5957-90f8-fd1ad820a2c5
DOI
10.1101/2025.06.20.660695
Open publication

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Epitope Effect Prevalence in Affinity-based pQTL studiesDOI 10.1101/2025.06.20.660695
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