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An Integrated Large-Scale Atlas of Protein Quantitative Trait Loci across Olink and SomaScan platforms

2025-10-07

Abstract excerpt

Protein quantitative trait loci (pQTLs) provide insight into the genetic regulation of protein expression and disease biology. We performed a large-scale cross-platform meta-analysis of plasma proteomics, integrating data from over 90,000 individuals across Olink and SomaScan platforms. This effort identified >30,000 sentinel pQTLs, with multi-trait approach (MTAG) markedly boosting both discovery and replication,...

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Literature Corpus work
55e6ff92-431b-5669-bdf0-b5f2d10e6aef
DOI
10.1101/2025.10.06.25336803
Open publication

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An Integrated Large-Scale Atlas of Protein Quantitative Trait Loci across Olink and SomaScan platformsDOI 10.1101/2025.10.06.25336803
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