Connecting genetic risk to disease end points through the human blood plasma proteome.

doi:10.1038/ncomms14357

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Article

Connecting genetic risk to disease end points through the human blood plasma proteome.

Nature communications - 27 Feb 2017

Suhre Karsten, Arnold Matthias, Bhagwat Aditya Mukund, Cotton Richard J, Engelke Rudolf, Raffler Johannes, Sarwath Hina, Thareja Gaurav, Wahl Annika, DeLisle Robert Kirk, Gold Larry, Pezer Marija, Lauc Gordan, El-Din Selim Mohammed A, Mook-Kanamori Dennis O, Al-Dous Eman K, Mohamoud Yasmin A, Malek Joel, Strauch Konstantin, Grallert Harald, Peters Annette, Kastenmüller Gabi, Gieger Christian, Graumann Johannes

Abstract excerpt

Genome-wide association studies (GWAS) with intermediate phenotypes, like changes in metabolite and protein levels, provide functional evidence to map disease associations and translate them into clinical applications. However, although hundreds of genetic variants have been associated with complex disorders, the underlying molecular pathways often remain elusive. Associations with intermediate traits are key in...

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PMID: 28240269
DOI: 10.1038/ncomms14357
PMCID: PMC5333359

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