Article
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform.
Nature genetics - 1 Dec 2025
Suhre Karsten, Chen Qingwen, Halama Anna, Mendez Kevin, Dahlin Amber, Stephan Nisha, Thareja Gaurav, Sarwath Hina, Guturu Harendra, Dwaraka Varun B, Smith Ryan, Batzoglou Serafim, Schmidt Frank, Lasky-Su Jessica A
Abstract excerpt
Most studies to date of protein quantitative trait loci (pQTLs) have relied on affinity proteomics platforms, which provide only limited information about the targeted protein isoforms and may be affected by genetic variation in their epitope binding. Here we show that mass spectrometry (MS)-based proteomics can complement these studies and provide insights into the role of specific protein isoform and...
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