Article
Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods.
Science advances - 19 Aug 2022
Katz Daniel H, Robbins Jeremy M, Deng Shuliang, Tahir Usman A, Bick Alexander G, Pampana Akhil, Yu Zhi, Ngo Debby, Benson Mark D, Chen Zsu-Zsu, Cruz Daniel E, Shen Dongxiao, Gao Yan, Bouchard Claude, Sarzynski Mark A, Correa Adolfo, Natarajan Pradeep, Wilson James G, Gerszten Robert E
Abstract excerpt
High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used increasingly in human studies. However, direct analyses to address the relative strengths and weaknesses of these platforms are lacking. We assessed findings from the SomaScan1.3K (N = 1301 reagents), the SomaScan5K platform (N = 4979 reagents), and the Olink Explore (N = 1472 reagents) profiling techniques in 568 adults...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.