Article
Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease risk.
Nature genetics - 1 Aug 2026
Pietzner Maik, Williamson Alice, Hunt Karen A, Koprulu Mine, Kohleick Leonhard, Demircan Kamil, Finer Sarah, Carrasco Zanini Julia, van Heel David A, Langenberg Claudia
Abstract excerpt
Understanding genetic variation associated with differences in plasma protein levels can elucidate human disease mechanisms. Here we demonstrate how untargeted nanoparticle-enriched mass spectrometry (MS)-based plasma proteomics delivers quantitatively and qualitatively different insights compared to two affinity-based assays in a sample of ~1,400 British South Asian individuals. We identify >1,200 significant...
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