Article

Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activity

2022-04-21

Abstract excerpt

The interferon-induced transmembrane (IFITM) proteins broadly inhibit the entry of diverse pathogenic viruses, including Influenza A virus (IAV), Zika virus, HIV-1, and SARS coronaviruses by inhibiting virus-cell membrane fusion. IFITM3 was previously shown to disrupt cholesterol trafficking, but the functional relationship between IFITM3 and cholesterol remains unclear. We previously showed that inhibition of IAV...

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Identifiers and source

Literature Corpus work: df396da5-7075-52b2-bc8c-dad978604258
DOI: 10.1101/2022.04.21.488780

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