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Article

Opposing activities of IFITM proteins in SARS-CoV-2 infection.

The EMBO journal - 1 Feb 2021

Shi Guoli, Kenney Adam D, Kudryashova Elena, Zani Ashley, Zhang Lizhi, Lai Kin Kui, Hall-Stoodley Luanne, Robinson Richard T, Kudryashov Dmitri S, Compton Alex A, Yount Jacob S

Abstract excerpt

Interferon-induced transmembrane proteins (IFITMs) restrict infections by many viruses, but a subset of IFITMs enhance infections by specific coronaviruses through currently unknown mechanisms. We show that SARS-CoV-2 Spike-pseudotyped virus and genuine SARS-CoV-2 infections are generally restricted by human and mouse IFITM1, IFITM2, and IFITM3, using gain- and loss-of-function approaches. Mechanistically,...

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Source

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Identifiers

PMID: 33270927
DOI: 10.15252/embj.2020106501
PMCID: PMC7744865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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