Article
The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.
Journal of virology - 1 Jul 2013
John Sinu P, Chin Christopher R, Perreira Jill M, Feeley Eric M, Aker Aaron M, Savidis George, Smith Sarah E, Elia Andrew E H, Everitt Aaron R, Vora Mehul, Pertel Thomas, Elledge Stephen J, Kellam Paul, Brass Abraham L
Abstract excerpt
The interferon-induced transmembrane protein 3 (IFITM3) gene is an interferon-stimulated gene that inhibits the replication of multiple pathogenic viruses in vitro and in vivo. IFITM3 is a member of a large protein superfamily, whose members share a functionally undefined area of high amino acid conservation, the CD225 domain. We performed mutational analyses of IFITM3 and identified multiple residues within the...
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