Article

Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric state

2020-05-16

Abstract excerpt

The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. We identified a GxxxG motif in many CD225 proteins, including IFITM3 and proline rich transmembrane protein 2 (PRRT2). Mutation of PRRT2, a regulator of neurotransmitter release, at glycin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08977ddc-5898-5f2f-a9ee-cfbadd546300
DOI: 10.1101/2020.05.14.096891

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric stateDOI 10.1101/2020.05.14.096891Read

A novel domain within the CIL regulates egress of IFITM3 from the Golgi and prevents its deleterious accumulation in this apparatusSemantic proximity Read

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusionSemantic proximity Read

Cholesterol binds the amphipathic helix of IFITM3 and regulates antiviral activitySemantic proximity Read

The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.Semantic proximity Read

Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.Semantic proximity Read

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibilitySemantic proximity Read

Antiviral Protection by IFITM3 In VivoSemantic proximity Read

IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunitySemantic proximity Read

Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into VirionsSemantic proximity Read

IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infectionSemantic proximity Read

Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into Virions.Semantic proximity Read

Opposing roles of endosomal innate immunity proteins IFITM3 and TLR7 in human metapneumovirus infectionSemantic proximity Read