Article

Opposing activities of IFITM proteins in SARS-CoV-2 infection

2020-08-11

Abstract excerpt

Interferon-induced transmembrane proteins (IFITMs) restrict infections by many viruses, but a subset of IFITMs enhance infections by specific coronaviruses through currently unknown mechanisms. Here we show that SARS-CoV-2 Spike-pseudotyped virus and genuine SARS-CoV-2 infections are generally restricted by expression of human IFITM1, IFITM2, and IFITM3, using both gain- and loss-of-function approaches. Mechanisti...

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Literature Corpus work: d9225a49-5182-5982-a0ed-4ab93eceacb7
DOI: 10.1101/2020.08.11.246678

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