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Article

Antiviral Protection by IFITM3 In Vivo

3 Aug 2018

Abstract excerpt

Interferon-induced transmembrane protein 3 (IFITM3) is a cellular restriction factor that blocks fusion between virus and host membranes. Here, we provide an introduction to IFITM3 and the biochemical regulation underlying its antiviral activity. Further, we analyze and summarize the published literature examining phenotypes of IFITM3 knockout mice upon infections with viral pathogens and discuss the...

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PMID: 30662816
DOI: 10.1007/s40588-018-0103-0

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