Article

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibility

2026-08-22

Abstract excerpt

Genetic variation in interferon-induced transmembrane protein 3 (IFITM3) contributes to inter-individual differences in influenza outcome, yet a comprehensive functional map of IFITM3 variation remains unavailable. Here we show a high-resolution functional atlas of 2,898 IFITM3 variants across three influenza A strains using deep mutational scanning. Our data reveals a functionally constrained central region, prov...

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Literature Corpus work: da6e38c4-629b-579a-b525-9afe486f8b33
DOI: 10.1038/s42003-026-10800-0

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