Article

Alternative polyadenylation regulates human urothelial cell differentiation

2025-03-11

Abstract excerpt

The urothelium is stratified into progenitor basal cells, intermediate cells, and terminally differentiated umbrella cells. Proper renewal of umbrella cells is necessary for maintaining urinary tract barrier integrity. To investigate whether mRNA alternative cleavage and polyadenylation (APA) regulates urothelial differentiation, we developed a single-cell polyadenylation site usage (scPASU) computational pipeline...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de905edd-f953-51d0-9752-fb9a6b07357e
DOI: 10.1101/2025.03.03.641311

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative polyadenylation regulates human urothelial cell differentiationDOI 10.1101/2025.03.03.641311Read

A poly(A) isoform–aware single-cell and spatial atlas defines fibroblast niches in the human bladderSemantic proximity Read

Dynamic Analysis of Alternative Polyadenylation from Single-Cell RNA-Seq (scDaPars) Reveals Cell Subpopulations Invisible to Gene Expression AnalysisSemantic proximity Read

Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISOSemantic proximity Read

Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolutionSemantic proximity Read

Cell-type-specific alternative polyadenylation (APA) genes reveal the function of dynamic APA in complex tissuesSemantic proximity Read

Alternative polyadenylation characterizes epithelial and fibroblast phenotypic heterogeneity in pancreatic ductal adenocarcinomaSemantic proximity Read

A Spatially Resolved Atlas of Alternative Polyadenylation Across 18 Human Tissues and 76 Disease StatesSemantic proximity Read

scTail: precise polyadenylation site detection and its alternative usage analysis from reads 1 preserved 3’ scRNA-seq dataSemantic proximity Read

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and diseaseSemantic proximity Read

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read

Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq dataSemantic proximity Read

E2F mediates enhanced alternative polyadenylation in proliferationSemantic proximity Read