Article

scTail: precise polyadenylation site detection and its alternative usage analysis from reads 1 preserved 3’ scRNA-seq data

2024-07-09

Abstract excerpt

Three-prime single-cell RNA-seq (scRNA-seq) has been widely employed to dissect the variability of cellular transcriptomes, while only the cDNAs on reads 2 are routinely used, including to analyze polyadenylation sites (PAS). However, despite of high sequencing noise, we found the cDNAs on reads 1 are highly informative in precisely detecting PAS. Here, we further develop a computational method, scTail, to identif...

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Literature Corpus work: e0f82d64-1848-5af5-a68b-a860d5deb218
DOI: 10.1101/2024.07.05.602174

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