Article

A Spatially Resolved Atlas of Alternative Polyadenylation Across 18 Human Tissues and 76 Disease States

2025-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Alternative polyadenylation (APA) is a key regulator of gene expression and cellular dynamics, yet systematic investigations of spatially resolved APA across diverse human tissues remain limited. Here, we developed SpatialAPA ( https://github.com/Omicslab-Zhang/spatialAPA ), a framework that benchmarks multiple APA identification methods and integrates spatial APA data with gene expression and...

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Literature Corpus work: 93fc4496-6df8-54e2-b129-de5e8e2a5d6d
DOI: 10.1101/2025.08.27.672753

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