Article

Alternative polyadenylation characterizes epithelial and fibroblast phenotypic heterogeneity in pancreatic ductal adenocarcinoma

2021-09-19

Abstract excerpt

Human tumors are characterized by extensive intratumoral transcriptional variability within the cancer cell and stromal compartments. This variation drives phenotypic heterogeneity, producing cell states with differential pro- and anti-tumorigenic properties. While bulk RNA sequencing cannot achieve cell type specific transcriptional granularity, single cell sequencing has permitted an unprecedented view of these...

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Literature Corpus work: 3bab945b-80da-5bad-8687-e50dfbe2b565
DOI: 10.1101/2021.09.18.460907

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