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Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq data

1 Sept 2018

Abstract excerpt

BACKGROUND: Most eukaryotic protein-coding genes exhibit alternative cleavage and polyadenylation (APA), resulting in mRNA isoforms with different 3' untranslated regions (3' UTRs). Studies have shown that brain cells tend to express long 3' UTR isoforms using distal cleavage and polyadenylation sites (PASs). METHODS: Using our recently developed, comprehensive PAS database PolyA_DB, we developed an efficient...

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PMID: 31380142
DOI: 10.1007/s40484-018-0148-3

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