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Article

Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolution

27 Feb 2019

Abstract excerpt

Alternative polyadenylation (APA) has been discovered to play regulatory roles in the development of many cancer cells through preferential addition of a poly(A) tail at specific sites of pre-mRNA. A recent study found that APA was involved in the mediation of acute myeloid leukaemia (AML). However, unlike gene expression heterogeneity, little attention has been directed toward variations in single-cell APA for...

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PMID: 30810468
DOI: 10.1080/15476286.2019.1586139

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