Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E2F mediates enhanced alternative polyadenylation in proliferation

2 Jul 2012

Abstract excerpt

BACKGROUND: The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isoforms that differ in their 3' UTRs, thereby modulating genes' response to 3' UTR-mediated regulation. Enhanced cleavage at 3' UTR proximal poly(A) sites resulting in global 3' UTR shortening was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genetic Neurodegenerative Diseases
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22747694
DOI: 10.1186/gb-2012-13-7-r59

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E2F mediates enhanced alternative polyadenylation in proliferationPMID 22747694Read ↗

Shortening of 3’ UTRs in most cell types composing tumor tissues implicates alternative polyadenylation in protein metabolismSemantic proximity Read ↗

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and diseaseSemantic proximity Read ↗

APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoformsSemantic proximity Read ↗

A pan-cancer interrogation of intronic polyadenylation and its association with cancer characteristicsSemantic proximity Read ↗

Alternative Cleavage and Polyadenylation during Colorectal Cancer DevelopmentSemantic proximity Read ↗

Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA‐seq dataSemantic proximity Read ↗

A comprehensive analysis of 3’ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogenous ribonucleoprotein C on cleavage and polyadenylationSemantic proximity Read ↗

Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells.Semantic proximity Read ↗

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read ↗

Alternative polyadenylation characterizes epithelial and fibroblast phenotypic heterogeneity in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone processingSemantic proximity Read ↗

Alternative polyadenylation dysregulation contributes to the differentiation block of acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.